p53 Arg72Pro, MDM2 T309GandCCND1 G870Apolymorphisms are not associated with susceptibility to esophageal adenocarcinoma
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چکیده
منابع مشابه
Association of p53 Arg72Pro and MDM2 SNP309 polymorphisms with glioma.
Epidemiological studies of the association of variants p53 Arg72Pro and MDM2 single-nucleotide polymorphism 309 (SNP309) with glioma risk have produced inconsistent results. The aim of the current study was to evaluate the association of these 2 variants with glioma susceptibility using a meta-analysis approach. For p53 Arg72Pro, 10 case-control studies including 2587 glioma patients and 40...
متن کاملp53 Arg72Pro and MDM2 T309G polymorphisms, histology, and esophageal cancer prognosis.
PURPOSE This study aimed to evaluate the prognostic significance of two functional single nucleotide polymorphisms (SNP) in the p53 pathway (p53 Arg72Pro and MDM2 T309G) in patients with esophageal cancer, and to determine the importance of histologic subtype in the SNP-outcome relationships. EXPERIMENTAL DESIGN A cohort of 371 patients with esophageal carcinoma enrolled in Boston, USA from 1...
متن کاملvitiligo associated with esophageal adenocarcinoma
vitiligo is a disease that results in depigmented areas in the skin. it may develop at any age but the average age at onset is 20 years. association of vitiligo and melanoma has been commonly reported, but malignancies other than melanoma have been rarely associated with vitiligo. we report a 73‑year‑old patient with new onset vitiligo who developed esophageal adenocarcinoma in the following ye...
متن کاملIncreased Risk of Cutaneous Melanoma Associated with p53 Arg72Pro Polymorphism
OBJECTIVE The objective of this study was to test the hypothesis that p53 Arg72Pro polymorphism may contribute to an increased risk of cutaneous melanoma (CM). METHODS By searching the databases of PubMed, EMBASE, and Web of Science, a total of 8 eligible case-control studies with 1,957 CM cases and 2,887 controls were included in this meta-analysis. Stata software was used to analyze all the...
متن کاملThe significance of MDM2 SNP309 and p53 Arg72Pro in young women with breast cancer.
The p53 protein and its regulator MDM2 is central to tumorigenesis by directing cells to undergo cell cycle arrest and/or apoptosis in response to DNA damage or other stress signals. The genes encoding these proteins contain nucleotide variation (p53 codon 72, MDM2 SNP309) that influences cellular response. We examined the p53 codon 72 and MDM2 SNP309 to determine their implication with age of ...
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ژورنال
عنوان ژورنال: Diseases of the Esophagus
سال: 2010
ISSN: 1120-8694,1442-2050
DOI: 10.1111/j.1442-2050.2009.00960.x